Microarrays/Chips

More information can be found in chapter 10 Microarrays/Biochips in our Catalogue 2010/2011 - download now!

HTA^TM

High-Throughput microArraying

The complete deciphering of the human genome and the rapidly growing number of completely sequenced animal, plant and microbial genomes open up new investigative possibilities and techniques. Complex functional analyses, mutation detection or genotyping can be performed within

a few hours with the aid of microarrays or „biochips”. Greiner Bio-One develops and produces high-quality biochips for human diagnostics, consumer protection and quality control in the pharmaceutical industry. Our expertise encompasses the development and production of our own innovative biochip platforms for the parallel analysis of samples, the selection of probes, the validation and production of biochips as well as their certification as In-Vitro Diagnostic Devices according to the European Guideline 98/79/EC.

HTA^TMPlatforms

In academic research with “high-density microarrays”, some samples are investigated for thousands of parameters whilst compared to diagnostics thousands of samples are analysed for a few expressive markers. Therefore parallel comparison and automation play a decisive role. In order to take this into

account, Greiner Bio-One has developed new HTS platforms made from plastic especially for use in biochip technology – the HTA^TMPlatforms (High-Throughput microArraying).

HTA^TM Surfaces

Beside the multifunctional surface, Greiner Bio-One offers a proprietary 3-D chemistry, which achieves an excellent binding of molecules to the surface via ionic and covalent reaction pathways. The contact angle is about 45°. The advantages of the 3-D matrix include high sensitivity and a chemical and mechanical robustness that permits using contact as well as contact-free printing systems.

A large variety of user-specific applications can be covered with the help of the surfaces offered by Greiner Bio-One. The overview below can serve as an orientation aid for different microarray applications.

The high quality of the HTA^TM 3-D technology ensures an outstandingly uniform spot morphology and avoids variable background fluorescence which can arise due to unspecific binding. The reproducibility and reliability of the analysis results within an array and between arrays represent an important feature of the HTA^TM technology, which saves sample material, time and money.